Water → 4-(4-Fluorophenyl)quinazolin-2(1H)-one

HRID 2293616Notes

Reaction equation

HRID 2293616 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])=[CH:4][CH:3]=1.[NH2:17][C:18](N)=[O:19].O>CN1C(=O)CCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:15][C:18](=[O:19])[N:17]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1176UreaHCID 98372872-Amino-4'-fluorobenzophenone

Product 1

HCID 221016914-(4-Fluorophenyl)quinazolin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

4'-Fluoro-2-aminobenzophenone (164.5 g, 1.20 mol) is heated with urea (72.09 g, 0.500 mol) at 195° C. (1 h) in NMP (500 mL). The solution is cooled and poured into water (2 L). The product is collected by filtration and dried. The product is purified by recrystallization.

Workup

  1. temperatureThe solution is cooled
  2. filtrationThe product is collected by filtration
  3. customdried
  4. customThe product is purified by recrystallization

Sources & evidence

ORD record
ord-71d0ea32cfc249b5989d4d9cd4af68e5
Source dataset
uspto-grants-1997_11
Patent number
US05686560

Reaction notes

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