Water → HCID 10631480, compound

HRID 2293623Notes

Reaction equation

HRID 2293623 reaction equation
[C-:1]#[N:2].[Na+].Cl[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1.O>CS(C)=O>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1)#[N:2]

Participants

5

Reactant 3

HCID 962WaterHCID 8929Sodium CyanideHCID 21477483HCID 21477483, compound

Product 1

HCID 10631480HCID 10631480, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
60 °C

Procedure

NaCN (509 mg) in DMSO (4.25 ml) is added to 4-(6-chlorohexyl)pyridine (1.71 g) dissolved in DMSO (4.25 ml). The mixture is stirred at 60° C. for 3 hours, poured into water (100 ml) and extracted with chloroform (3×15 ml). The combined extracts are washed with water (2×20 ml), dried (Na2SO4) and the solvent evaporated to give 4-(6-cyanohexyl)-pyridine.

Workup

  1. extractionextracted with chloroform (3×15 ml)
  2. washThe combined extracts are washed with water (2×20 ml)
  3. dry with materialdried (Na2SO4)
  4. customthe solvent evaporated

Sources & evidence

ORD record
ord-8788f0f681684b998d3dd3813bef10b4
Source dataset
uspto-grants-1997_11
Patent number
US05686564

Reaction notes

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