Ammonia → HCID 57757887, compound

HRID 229367Notes

Reaction equation

HRID 229367 reaction equation
Cl[C:2]1[N:6]2[CH:7]=[CH:8][C:9]([C:11]3C=NC=C[CH:16]=3)=[CH:10][C:5]2=[N:4][C:3]=1[NH:17][C:18]([NH:20][CH2:21][CH3:22])=[O:19].N.C([OH:26])C>>[C:11]([C:9]1[CH:8]=[CH:7][N:6]2[CH:2]=[C:3]([NH:17][C:18]([NH:20][CH2:21][CH3:22])=[O:19])[N:4]=[C:5]2[CH:10]=1)(=[O:26])[CH3:16]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 702EthanolHCID 11483894HCID 11483894, compound

Product 1

HCID 57757887HCID 57757887, compoundYield 74%

Procedure

To a suspension of diester 2 (10.9 g, 31.9 mmol) in 50 mL ethanol was added 50 mL of 7M methanolic ammonia at 23° C. After 3 h, the copious precipitate was collected by vacuum filtration and dried under a stream of air to give 7.45 g (74%) of amide 3 as a white solid.

Workup

  1. filtrationthe copious precipitate was collected by vacuum filtration
  2. customdried under a stream of air

Sources & evidence

ORD record
ord-983b042b27df4f608bdd671445173960
Source dataset
uspto-grants-2009_07
Patent number
US07563788B2

Reaction notes

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