Piperazine → HCID 21477614, compound

HRID 2293740Notes

Reaction equation

HRID 2293740 reaction equation
Cl[C:2]1[C:7]([NH:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[N:6][CH:5]=[CH:4][N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:10][C:9]([NH:8][C:7]1[C:2]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[N:3][CH:4]=[CH:5][N:6]=1)([CH3:12])[CH3:11]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 21477647HCID 21477647, compound

Product 1

HCID 21477614HCID 21477614, compound

Procedure

Following the general procedure of PREPARATION 7 and making non-critical variations but starting with 2-chloro-3-(1,1-dimethylethylamino)pyrazine (PREPARATION 8, 0.95 g) and piperazine, the title compound is obtained, NMR (CDCl3) 1.47, 1.70, 2.99, 5.02, 7.46 and 7.69 δ.

Workup

  1. customthe general procedure of PREPARATION 7

Sources & evidence

ORD record
ord-5e0ea61edf6542d8b3cd8bcb2c2d83da
Source dataset
uspto-grants-1997_11
Patent number
US05686610

Reaction notes

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