1-[5-Chloro-4-(1-methylethyl)amino-3-pyridazinyl]piperazine → 1-[4-(1-Methylethyl)amino-3-pyridazinyl]piperazine

HRID 2293744Notes

Reaction equation

HRID 2293744 reaction equation
Cl[C:2]1[C:3]([NH:14][CH:15]([CH3:17])[CH3:16])=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[N:5]=[N:6][CH:7]=1>C(N(CC)CC)C>[CH3:17][CH:15]([NH:14][C:3]1[CH:2]=[CH:7][N:6]=[N:5][C:4]=1[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)[CH3:16]

Participants

3

Reactant 1

HCID 214776731-[5-Chloro-4-(1-methylethyl)amino-3-pyridazinyl]piperazine

Product 1

HCID 214776131-[4-(1-Methylethyl)amino-3-pyridazinyl]piperazine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following the general procedure of PREPARATION 10 and making non-critical variations but starting with 1-[5-chloro-4-(1-methylethyl)amino-3-pyridazinyl]piperazine (PREPARATION 42, 1.7 g) and triethylamine (0.81 g), the title compound is obtained, NMR (CDCl3) 1.28, 2.06, 3.05, 3.11, 3.59, 4.75, 6.39, and 8.49 δ; CMR (CDCl3) 22.2, 43.2, 46.2, 50.6, 103.7, 138.7, 148.4 and 154.5 δ.

Workup

  1. customthe general procedure of PREPARATION 10

Sources & evidence

ORD record
ord-b4fff19ccddf4abd9dc13f2ebea2e896
Source dataset
uspto-grants-1997_11
Patent number
US05686610

Reaction notes

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