1-Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazine → 1-[3-(1,1-Dimethylethylamino)pyridyl]piperazine

HRID 2293775ノート

反応式

HRID 2293775 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([NH:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[CH:18][CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:24][C:21]([NH:20][C:19]1[C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:15][CH:16]=[CH:17][CH:18]=1)([CH3:22])[CH3:23]

参加物

5

反応物 2

HCID 214776231-Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 110426831-[3-(1,1-Dimethylethylamino)pyridyl]piperazine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1-Benzyl-4-[3-(1,1-dimethylethylamino)pyridyl]piperazine (PREPARATION 96, 4.25 g, 13.10 mmol) is dissolved in 100 ml ethanol. Palladium (10% on carbon, 1.0 g) is added and the solution hydrogenated at 40 psi hydrogen gas. The mixture is filtered and concentrated to give the title compound, NMR (300 MHz, CD3OD) 7.53, 7.19, 6.93, 2.95, 1.39 δ.

後処理

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-d9140f8d7cc34a82bf8044317997d335
出典データセット
uspto-grants-1997_11
特許番号
US05686610

反応ノート

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