Acetic Acid → HCID 3666021, Verbindung

HRID 2293874Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2293874
[O-]CC.[Na+].[C:5]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)(=[O:7])[CH3:6].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1.C(O)(=O)C>CCO>[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)=[O:7])=[CH:16][CH:15]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 69202-AcetylthiopheneHCID 680234-FluorobenzaldehydeHCID 2723922Sodium ethoxide

Produkt 1

HCID 3666021HCID 3666021, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of sodium ethoxide (21% by weight in EtOH, 0.68 gm, 10 mmol) was added to a solution of 2-acetylthiophene (12.60 gm, 100 mmol, from Aldrich) and 4-fluorobenzaldehyde (12.41 gm, 100 mmol, from Aldrich) in EtOH (50 ml) and the mixture stirred under argon for 15 minutes. More EtOH (25 ml) was then added to make a slurry of the reaction mixture, which had partially solidified. Acetic acid (0.60 gm, 11 mmol) was added and a yellow solid filtered out of solution. The solid was recrystallized from EtOAc and hexane to afford the title compound as long, pale yellow needles (17.679 gm, 71%).

Aufarbeitung

  1. filtrationa yellow solid filtered out of solution
  2. customThe solid was recrystallized from EtOAc and hexane

Quellen und Nachweise

ORD-Eintrag
ord-bc02f72ba0a847fca00ae34dcad3b1c1
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05686433

Notizen zur Reaktion

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