2-(4-fluorophenyl)-1-phenylethanone → HCID 54455826, compound

HRID 2293969Notes

Reaction equation

HRID 2293969 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)=[CH:4][CH:3]=1.Cl.[O:18]([NH2:20])[CH3:19]>N1C=CC=CC=1>[CH3:19][O:18][N:20]=[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1

Participants

4

Reactant 2

HCID 2363292-(4-fluorophenyl)-1-phenylethanoneHCID 521874O-Methylhydroxylamine hydrochloride

Product 1

HCID 54455826HCID 54455826, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of 2-(4-fluorophenyl)-1-phenyl-1-ethanone (5 g, 30 mmol) in 30 ml pyridine under nitrogen was added methoxylamine hydrochloride (3.8 g, 45 mmol) at 25° C. The resulting mixture was stirred at 25° C. for 17 hours. The pyridine was removed in vacuo with heating. The residual solids were a mixture of the oxime geometrical isomers as a white syrup and it was used for the next step without further purification. Rf : 0.48, 0.70 (CH2C12).

Workup

  1. customThe pyridine was removed in vacuo
  2. temperaturewith heating
  3. additiona mixture of the oxime geometrical isomers as a white syrup and it
  4. customwas used for the next step without further purification

Sources & evidence

ORD record
ord-a5c4beae8db24ec0b2df607fd6a23ebe
Source dataset
uspto-grants-1997_11
Patent number
US05688789

Reaction notes

Loading…