Hydrochloric Acid → 3-Methoxy-4-phenylaminopyrrolidine hydrochloride

HRID 2293994Notes

Reaction equation

HRID 2293994 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([O:20][CH3:21])[CH2:9]1)=O)(C)(C)C.[ClH:22]>CO>[ClH:22].[CH3:21][O:20][CH:10]1[CH:11]([NH:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:12][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214733421-t-Butoxycarbonyl-3-methoxy-4-phenylaminopyrrolidine

Product 1

HCID 214733543-Methoxy-4-phenylaminopyrrolidine hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 100 ml of methanol was dissolved 1.98 g (0.0068 mole) of 1-t-butoxycarbonyl-3-methoxy-4-phenylaminopyrrolidine obtained as described above, and 23.5 ml of 6N hydrochloric acid was added thereto. The mixture was left to stand at room temperature overnight. The solvent was removed under reduced pressure, and the residue was washed with ethanol to obtain 1.71 g of 3-methoxy-4-phenylaminopyrrolidine hydrochloride as white powder.

Workup

  1. customobtained
  2. additionwas added
  3. waitThe mixture was left
  4. customThe solvent was removed under reduced pressure
  5. washthe residue was washed with ethanol

Sources & evidence

ORD record
ord-0cc71dc497264b3cb7f2d3b3eb386623
Source dataset
uspto-grants-1997_11
Patent number
US05688791

Reaction notes

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