Hydrochloric Acid → HCID 71433854, compound

HRID 2293997Notes

Reaction equation

HRID 2293997 reaction equation
C(OC[O:5][C:6]1[C:11]2=[N:12][C:13]([CH3:35])=[C:14]([CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][CH:22]([C:25]4[C:29]5[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:28]=5[O:27][N:26]=4)[CH2:21][CH2:20]3)[C:15](=[O:16])[N:10]2[CH:9]=[CH:8][CH:7]=1)C.C(O)C.[ClH:39]>>[ClH:39].[ClH:39].[F:34][C:32]1[CH:31]=[CH:30][C:29]2[C:25]([CH:22]3[CH2:21][CH2:20][N:19]([CH2:18][CH2:17][C:14]4[C:15](=[O:16])[N:10]5[CH:9]=[CH:8][CH:7]=[C:6]([OH:5])[C:11]5=[N:12][C:13]=4[CH3:35])[CH2:24][CH2:23]3)=[N:26][O:27][C:28]=2[CH:33]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 21473720HCID 21473720, compound

Product 1

HCID 71433854HCID 71433854, compoundYield 95.7%

Procedure

A mixture of 9-(ethoxymethoxy)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (0.008 mol) in hydrochloric acid, 12N (25 ml) and ethanol (100 ml) was stirred and refluxed for 6 hours. The reaction mixture was cooled and the precipitate was filtered off and dried, yielding 4 g (95.7%) 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one.dihydrochloride.sesquihydrate; mp. 288.3° C. (interm. 18).

Workup

  1. temperaturerefluxed for 6 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationthe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-30b9713d36be42969d6751058f851c2d
Source dataset
uspto-grants-1997_11
Patent number
US05688799

Reaction notes

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