Hydrochloric Acid → 5-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-2-methyl-pyrimidin-4-ylamine dihydrochloride

HRID 2294005Notes

Reaction equation

HRID 2294005 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][N:11]([CH2:14][C:15]3[C:16]([NH2:22])=[N:17][C:18]([CH3:21])=[N:19][CH:20]=3)[CH2:12][CH:13]=2)=[CH:4][CH:3]=1.[ClH:23]>C(O)C>[ClH:23].[ClH:23].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[C:16]([NH2:22])=[N:17][C:18]([CH3:21])=[N:19][CH:20]=3)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214736285-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-2-methyl-pyrimidin-4-ylamine

Product 1

HCID 214736465-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-2-methyl-pyrimidin-4-ylamine dihydrochlorideYield 54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.2 g (0.011 mol) of 5-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-2-methyl-pyrimidin-4-ylamine were dissolved in ethanol and treated with excess ethanolic hydrochloric acid. Crystals separated from the solution. 2.2 g (54%) of 5-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-ylmethyl]-2-methyl-pyrimidin-4-ylamine dihydrochloride were obtained as pale yellow crystals; m.p. 262°-264°.

Workup

  1. customCrystals separated from the solution

Sources & evidence

ORD record
ord-991e626a125441fb91b7f268418b0801
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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