反应详情

A solution of 0.177 g (0.00053 mol) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl )-pyrimidin-4-ylamine in 20 ml of ethanol was treated with 0.15 ml (0.000525 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from ethanol/diethyl ether. 0.10 g (47%) of 2-methyl-5-(6-phenyl-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 212°-214°.

1. customthe residue was recrystallized from ethanol/diethyl ether