Hydrochloric Acid → 5-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride

HRID 2294016Notes

Reaction equation

HRID 2294016 reaction equation
[CH2:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH2:4][CH2:3][N:2]1[CH2:11][C:12]1[C:13]([NH2:19])=[N:14][C:15]([CH3:18])=[N:16][CH:17]=1.[ClH:20]>C(O)C>[ClH:20].[ClH:20].[CH2:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH2:4][CH2:3][N:2]1[CH2:11][C:12]1[C:13]([NH2:19])=[N:14][C:15]([CH3:18])=[N:16][CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214736565-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine

Product 1

HCID 214736845-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochlorideYield 97%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1.74 g (0.00673 mol) of 5-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine in 40 ml of ethanol was treated with 3.85 ml (0.0135 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 2.16 g (97%) of 5-(3,4,5,6,7,8-hexahydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride were obtained as white crystals; m.p. 248°-250°.

Workup

  1. customthe residue was recrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-fef790fa3f8a4d7cb96a6972e07ce034
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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