Hydrochloric Acid → 5-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294033Notes

Reaction equation

HRID 2294033 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[C:1]1([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214736725-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine

Product 1

HCID 214737025-(4-Phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochlorideYield 99.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.17 g (0.00059 mol) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 120 ml of hot methanol. The solution was treated at room temperature with 0.32 ml (0.00118 mol) of 3.7N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.21 g (71%) of 5-(4-phenyl-piperazin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as white crystals; m.p. 275°-277°.

Workup

  1. customthe residue was recrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-945448211fc845539079e982daa62383
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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