Hydrochloric Acid → 5-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride

HRID 2294035Notes

Reaction equation

HRID 2294035 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[C:16]([NH2:22])=[N:17][C:18]([NH2:21])=[N:19][CH:20]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[C:16]([NH2:22])=[N:17][C:18]([NH2:21])=[N:19][CH:20]=3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214736515-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine

Product 1

HCID 214736885-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochlorideYield 221.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.18 g (0.00056 mol) of 5-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine was dissolved in 250 ml of hot methanol. The solution was treated at room temperature with 0.32 ml (0.00112 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.22 g (100%) of 5-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride (1:1.9) was obtained as white crystals; m.p. 252°-253°.

Workup

  1. customthe residue was recrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-9c45314138d041139465dd87c55045b8
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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