反应详情

0.18 g (0.00056 mol) of 5-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine was dissolved in 250 ml of hot methanol. The solution was treated at room temperature with 0.32 ml (0.00112 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.22 g (100%) of 5-[4-(4-chloro-phenyl)-piperazin-1-ylmethyl]-pyrimidine-2,4-diamine hydrochloride (1:1.9) was obtained as white crystals; m.p. 252°-253°.

1. customthe residue was recrystallized from methanol/diethyl ether