Hydrochloric Acid → 5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride

HRID 2294044Notes

Reaction equation

HRID 2294044 reaction equation
[C:1]1([C:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:22]>CO>[ClH:22].[ClH:22].[C:1]1([C:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[C:15]([NH2:21])=[N:16][C:17]([NH2:20])=[N:18][CH:19]=3)[CH2:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 214736165-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidine-2,4-diamine

Product 1

HCID 214736895-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochlorideYield 80.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.23 g (0.00081 mol) of 5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidine-2,4-diamine was dissolved in 220 ml of hot methanol. The solution was treated at room temperature with 0.47 ml (0.00162 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol/diethyl ether. 0.23 g (79%) of 5-(4-phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-pyrimidine-2,4-diamine dihydrochloride was obtained as white crystals; m.p. 209°-211°.

Workup

  1. customthe residue was recrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-84806dd2961346ae8d1d59ace003fba7
Source dataset
uspto-grants-1997_11
Patent number
US05688798

Reaction notes

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