1-[2-(2-Oxazolyl)phenyl]-4-(phenylmethyl)piperazine → HCID 10657035, compound

HRID 2294112Notes

Reaction equation

HRID 2294112 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]2[O:21][CH:22]=[CH:23][N:24]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[O:21]1[CH:22]=[CH:23][N:24]=[C:20]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 105676521-[2-(2-Oxazolyl)phenyl]-4-(phenylmethyl)piperazine

Product 1

HCID 10657035HCID 10657035, compoundYield 73.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 4-benzyl-1-(2-oxazol-2-ylphenyl)piperazine (0.906 g, 2.84 mmol) and 10% palladium on carbon (1 g) in 20 mL of methanol was stirred under a hydrogen atmosphere (1 atm) at room temperature for 4 hours. The mixture was filtered and concentrated by rotary evaporation to give 1-(2-oxazol-2-ylphenyl)piperazine (0.480 g, 2.1 mmol).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated by rotary evaporation

Sources & evidence

ORD record
ord-f8607d66318448df9a28b7a0260f066a
Source dataset
uspto-grants-1997_11
Patent number
US05688795

Reaction notes

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