Acrylamide → HCID 10849160, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2-methoxyphenyl)piperazine hydrochloride (22 g, 96.2 mmol), acrylamide (7.5 g, 106 mmol) and potassium carbonate (20 mL, 5M, 100 mmol) in 110 mL of water was heated at 80° C. for 2 hours to give a suspension. The suspension was allowed to cool to room temperature and filtered. The filtered residue was washed with water (3×30 mL) and dried under reduced pressure at 85° C. for 16 hours to give 3-[4-(2-methoxyphenyl)-piperazin-1-yl]propionamide (22.67 g, 86.1 mol), m.p. 145°-146° C.

Provenance & Evidence