Acrylamide → HCID 10849160, compound

HRID 2294120Notes

Reaction equation

HRID 2294120 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.[C:16]([NH2:20])(=[O:19])[CH:17]=[CH2:18].C(=O)([O-])[O-].[K+].[K+]>O>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:18][CH2:17][C:16]([NH2:20])=[O:19])[CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 6579AcrylamideHCID 11430Potassium CarbonateHCID 9899402N-(2-Methoxyphenyl)piperazine hydrochloride

Product 1

HCID 10849160HCID 10849160, compoundYield 89,501%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1-(2-methoxyphenyl)piperazine hydrochloride (22 g, 96.2 mmol), acrylamide (7.5 g, 106 mmol) and potassium carbonate (20 mL, 5M, 100 mmol) in 110 mL of water was heated at 80° C. for 2 hours to give a suspension. The suspension was allowed to cool to room temperature and filtered. The filtered residue was washed with water (3×30 mL) and dried under reduced pressure at 85° C. for 16 hours to give 3-[4-(2-methoxyphenyl)-piperazin-1-yl]propionamide (22.67 g, 86.1 mol), m.p. 145°-146° C.

Workup

  1. customto give a suspension
  2. temperatureto cool to room temperature
  3. filtrationfiltered
  4. washThe filtered residue was washed with water (3×30 mL)
  5. customdried under reduced pressure at 85° C. for 16 hours

Sources & evidence

ORD record
ord-e548ad937473435cae26f9ebb6fb1582
Source dataset
uspto-grants-1997_11
Patent number
US05688795

Reaction notes

Loading…