2-Chloro-N-methoxy-N-methylnicotinamide → HCID 21473428, compound

HRID 2294135Notes

Reaction equation

HRID 2294135 reaction equation
[F:1][C:2]([F:22])([F:21])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][NH2:20])[CH2:13][CH2:12]1.[Cl:23][C:24]1[N:35]=[CH:34][CH:33]=[CH:32][C:25]=1[C:26]([N:28]([O:30][CH3:31])[CH3:29])=[O:27]>>[ClH:23].[F:22][C:2]([F:1])([F:21])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:12][CH2:13][N:14]([CH2:17][CH2:18][CH2:19][NH:20][C:24]2[N:35]=[CH:34][CH:33]=[CH:32][C:25]=2[C:26]([N:28]([O:30][CH3:31])[CH3:29])=[O:27])[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 102360762-Chloro-N-methoxy-N-methylnicotinamideHCID 105674903-{4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazin-1-yl}propylamine

Product 1

HCID 21473428HCID 21473428, compound

Procedure

substituting 3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propylamine and 2-chloro-N-methoxy-N-methylnicotinamide gave 2-(3-{4-[2-(2,2,2-trifluoroethoxy)phenyl]piperazin-1-yl}propylamino)-N-methoxy-N -methylnicotinamide hydrochloride, m.p. 161°-177° C.; Anal.: Calcd. for C23H30F3N5 O3.(HCl)1.75.(C4H8O)0.1 : C, 55.79; H, 7.04; N, 14.78%; Found: C, 55.83; H, 6.92; N, 14.69%;

Sources & evidence

ORD record
ord-a064cc8edaa445059a81307bd3463570
Source dataset
uspto-grants-1997_11
Patent number
US05688795

Reaction notes

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