反应详情

A solution of 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylbenzamide (0.55 g, 1.39 mmol) in 2 mL of 5% methanol/methylene chloride was acidified with 1.4 mL of 1M hydrochloric acid in methanol and then ether was added to give a precipitate. The supernatant was decanted and the precipitate was washed with ether, collected and dried to give 2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylbenzamide hydrochloride (0.56 g, 1.27 mmol), m.p. 74°-79° C. Anal.: Calcd. for C23H32N4O2.HCl.(H2O)0.5 : C, 62.50; H, 7.75; N, 12.68%; Found: C, 62.27; H, 7.85; N, 13.02%.

1. customto give a precipitate
2. customThe supernatant was decanted
3. washthe precipitate was washed with ether
4. customcollected
5. customdried