反应详情

A solution of 2-{3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl-amino}-N,N-dimethylbenzamide (265 mg, 0.61 mmol) in 0.4 mL of 5% methanol/methylene chloride was acidified with 2 mL of 1M hydrochloric acid in methanol and then ether was added to give a precipitate. The supernatant was decanted and the precipitate was washed with ether, collected and dried to give 2-{3-[4-(5-chloro-2-methoxyphenyl)-piperazin-1-yl]propylamino}-N,N-dimethylbenzamide hydrochloride (270 mg, 0.57 mmol), m.p. 90°-135° C. Anal.: Calcd. for C23H31ClN4O2.HCl.(H2 O)0.5 : C, 57.98; H, 6.98; N, 11.76%; Found: C, 57.79H, 6.80; N, 11.72%.

1. customto give a precipitate
2. customThe supernatant was decanted
3. washthe precipitate was washed with ether
4. customcollected
5. customdried