Hydrochloric Acid → 2-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide hydrochloride

HRID 2294155Notes

Reaction equation

HRID 2294155 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:28]=[CH:27][CH:26]=[CH:25][C:19]=3[C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:10][CH2:9]2)=[C:4]([O:29][CH3:30])[CH:3]=1.[ClH:31]>C(Cl)Cl.CO>[ClH:31].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]3[N:28]=[CH:27][CH:26]=[CH:25][C:19]=3[C:20]([N:22]([CH3:24])[CH3:23])=[O:21])[CH2:12][CH2:13]2)=[C:4]([O:29][CH3:30])[CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 214734832-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide

Product 1

HCID 214734852-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

The 2-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide (0.19 g, 0.40 mmol) was dissolved in methylene chloride and the solution was treated with excess hydrochloric acid in methanol and concentrated to dryness. The residue was triturated with ethyl acetate and dried to give 2-{3-[4-(4-bromo-2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N -dimethylnicotinamide hydrochloride. Anal.: Calcd. for C22H30 BrN5O2.(HCl)2.H2O: C, 46.96; H, 6.37; N, 11.60%; Found: C, 46.56H, 6.37; N, 11.60%.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was triturated with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-aa7790bc74c049e599b1cf733a5b6a02
Source dataset
uspto-grants-1997_11
Patent number
US05688795

Reaction notes

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