Dimethylformamide → HCID 136395944, compound

HRID 2294170Notes

Reaction equation

HRID 2294170 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([OH:12])[N:6]=[C:5]2[N:13]([NH2:19])C(OCC)=O.CN(C)[CH:22]=[O:23]>>[F:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[N:6]3[C:22](=[O:23])[NH:19][N:13]=[C:5]3[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 178473571HCID 178473571, compound

Product 1

HCID 136395944HCID 136395944, compound

Procedure

3.7 g (0.014 mol) of ethyl 6-fluoro-2-hydroxy-quinazolin-4-yl-carbazate in 75 ml of dimethylformamide were boiled under reflux for 2 hrs. The reaction mixture was cooled to room temperature and then poured on to ice-water. The precipitate was filtered off, washed with acetone and dried in a vacuum. Yield: 1.7 g (56%) of 9-fluoro-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione as yellowish crystals; m.p. >350° C.

Workup

  1. temperatureunder reflux for 2 hrs
  2. filtrationThe precipitate was filtered off
  3. washwashed with acetone
  4. customdried in a vacuum

Sources & evidence

ORD record
ord-0c907f5cd6aa40898463f62a7cf17313
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

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