Stannous Chloride → HCID 136395946, compound

HRID 2294185Notes

Reaction equation

HRID 2294185 reaction equation
[Sn](Cl)[Cl:2].[N+:4]([C:7]1[CH:8]=[CH:9][C:10]2[C:11]3[N:12]([C:18](=[O:21])[NH:19][N:20]=3)[C:13](=[O:17])[NH:14][C:15]=2[CH:16]=1)([O-])=O>Cl>[ClH:2].[NH2:4][C:7]1[CH:8]=[CH:9][C:10]2[C:11]3[N:12]([C:18](=[O:21])[NH:19][N:20]=3)[C:13](=[O:17])[NH:14][C:15]=2[CH:16]=1

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 136395954HCID 136395954, compound

Product 1

HCID 136395946HCID 136395946, compoundYield 62.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1.98 g (8.8 mmol) of tin dichloride were dissolved in 10 ml of conc. hydrochloric acid at 80° C. 494 mg (2 mmol) of 8-nitro-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione were added portionwise thereto. After heating at reflux for 2 hrs. the precipitate was filtered off, washed with water and dried in a vacuum. 315 mg (62%) of 8-amino-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione hydrochloride were obtained as white crystals;

Workup

  1. temperatureAfter heating
  2. temperatureat reflux for 2 hrs
  3. filtrationthe precipitate was filtered off
  4. washwashed with water
  5. customdried in a vacuum

Sources & evidence

ORD record
ord-344d19fe978f4e8fb1ea0dbb2776998b
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

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