Stannous Chloride → HCID 136395955, compound

HRID 2294186Notes

Reaction equation

HRID 2294186 reaction equation
[Sn](Cl)[Cl:2].[Cl:4][C:5]1[C:6]([N+:20]([O-])=O)=[CH:7][C:8]2[C:9]3[N:10]([C:16](=[O:19])[NH:17][N:18]=3)[C:11](=[O:15])[NH:12][C:13]=2[CH:14]=1>Cl>[ClH:2].[NH2:20][C:6]1[C:5]([Cl:4])=[CH:14][C:13]2[NH:12][C:11](=[O:15])[N:10]3[C:16](=[O:19])[NH:17][N:18]=[C:9]3[C:8]=2[CH:7]=1

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 136395957HCID 136395957, compound

Product 1

HCID 136395955HCID 136395955, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

672 mg (2.98 mmol) of tin dichloride were dissolved in 3.4 ml of conc. hydrochloric acid at 80° C. 200 mg (0.71 mmol) of 8-chloro-9-nitro-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione were added portionwise thereto. After heating at reflux for 2 hrs. the precipitate was filtered off, washed with water and dried in a vacuum. 137 mg (67%) of 9-amino-8-chloro-2,3,5,6-tetrahydro-1,2,4-triazolo[4,3-c]quinazoline-3,5-dione hydrochloride were obtained as white crystals;

Workup

  1. temperatureAfter heating
  2. temperatureat reflux for 2 hrs
  3. filtrationthe precipitate was filtered off
  4. washwashed with water
  5. customdried in a vacuum

Sources & evidence

ORD record
ord-9240cd0310dc430a96d59363fbcc580d
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

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