Hydrazine hydrate (1:1) → HCID 178518778, compound

HRID 2294194Notes

Reaction equation

HRID 2294194 reaction equation
O[CH:2]1[C:14]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=[C:6]([OH:15])[C:5]=2[C:4](=O)[O:3]1.O.[NH2:18][NH2:19]>CS(C)=O>[OH:15][C:6]1[C:5]2[C:4](=[O:3])[NH:18][N:19]=[CH:2][C:14]=2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178519216HCID 178519216, compound

Product 1

HCID 178518778HCID 178518778, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

0.54 g (0.0025 mol) of (RS)-1,4-dihydroxy-1,3-dihydrofuro[3,4-c]quinolin-3-one was dissolved in 5 ml of dimethyl sulphoxide while gassing with argon. 0.125 g (0.0025 mol) of hydrazine hydrate was added thereto and the mixture was stirred at room temperature for 4 days. The suspension obtained was suction filtered and rinsed with ethyl acetate. Yield: 0.28 g (53%) of 5-hydroxy-3,4-dihydro-pyridazino[4,5-c]quinolin-4-one as yellow crystals; m.p. >350° C.

Workup

  1. customThe suspension obtained
  2. filtrationfiltered
  3. washrinsed with ethyl acetate

Sources & evidence

ORD record
ord-d56c6582967e42479d5559fc383db72f
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

Loading…