Hydrazine hydrate (1:1) → HCID 178518782, compound

HRID 2294196Notes

Reaction equation

HRID 2294196 reaction equation
[Cl:1][C:2]1[C:3]([Cl:18])=[CH:4][C:5]2[C:6]3[CH:15](O)[O:14][C:13](=O)[C:7]=3[C:8]([OH:12])=[N:9][C:10]=2[CH:11]=1.O.[NH2:20][NH2:21]>CS(C)=O>[Cl:1][C:2]1[C:3]([Cl:18])=[CH:4][C:5]2[C:6]3[CH:15]=[N:21][NH:20][C:13](=[O:14])[C:7]=3[C:8]([OH:12])=[N:9][C:10]=2[CH:11]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178519220HCID 178519220, compound

Product 1

HCID 178518782HCID 178518782, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1.76 g (0.0062 mol) of (RS)-7,8-dichloro-1,4-dihydroxy-1,3-dihydro-furo[3,4-c]quinolin-3-one were dissolved in 18 ml of dimethyl sulphoxide while gassing with argon. 0.31 g (0.0062 mol) of hydrazine hydrate was added thereto and the mixture was stirred at room temperature for 42 hrs. The suspension obtained was suction filtered and rinsed with ethyl acetate. Yield: 0.32 g (18%) of 8,9-dichloro-5-hydroxy-3,4-dihydro-pyridazino[4,5-c]quinolin-4-one as yellow crystals; m.p. >350° C.

Workup

  1. customThe suspension obtained
  2. filtrationfiltered
  3. washrinsed with ethyl acetate

Sources & evidence

ORD record
ord-6ec5ee4c6f744d95a7ef7e01172f1ca1
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

Loading…