HCID 21474274, compound → HCID 21474317, compound

HRID 2294249Notes

Reaction equation

HRID 2294249 reaction equation
C([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH:17]([OH:20])[CH2:18][OH:19])[C:10]=1[CH:21]([OH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)C1C=CC=CC=1>ClCCl.C(O)C>[OH:20][CH:17]([CH2:18][OH:19])[CH2:16][N:11]1[CH:12]=[CH:13][C:14](=[O:15])[C:9]([OH:8])=[C:10]1[CH:21]([OH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 1

HCID 21474274HCID 21474274, compound

Product 1

HCID 21474317HCID 21474317, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

3-Benzyloxy-1-(2,3-dihydroxy-propyl)-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one: From 2.1 g of 3-benzyloxy-1-(2,3-dihydroxy-propyl)-2-[phenyl-(tetrahydropyran-2-yloxy)methyl]-1H-pyridin-4-one there is obtained analogously to Example 6e, after chromatography: 3-benzyloxy-1-(2,3-dihydroxy-propyl)-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one. Colourless foam, diastereoisomeric mixture. Rf value 0.22 (silica gel 60, dichloromethane/ethanol 4/1).

Sources & evidence

ORD record
ord-cbd8224ab0cc482897a18aff37ce60cf
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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