HCID 21474287, compound → HCID 21474470, compound

HRID 2294250Notes

Reaction equation

HRID 2294250 reaction equation
C([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][N:18]([CH3:20])[CH3:19])[C:10]=1[CH:21]([OH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)C1C=CC=CC=1>ClCCl.C(O)C>[CH3:19][N:18]([CH3:20])[CH2:17][CH2:16][N:11]1[CH:12]=[CH:13][C:14](=[O:15])[C:9]([OH:8])=[C:10]1[CH:21]([OH:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 1

HCID 21474287HCID 21474287, compound

Product 1

HCID 21474470HCID 21474470, compound

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

3-Benzyloxy-1-(2-dimethylamino-ethyl)-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one: From 5.2 g of 3-benzyloxy-1-(2-dimethylamino-ethyl)-2-[phenyl-(tetrahydropyran-2-yloxy)-methyl]-1H-pyridin-4-one there is obtained analogously to Example 6e, after chromatography: 3-benzyloxy-1-(2-dimethylamino-ethyl)-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one. Beige, amorphous foam. Rf value: 0.16 (silica gel 60, dichloromethane/ethanol 4/1).

Sources & evidence

ORD record
ord-90061a984c6c408eacd01d85e85c393d
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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