HCID 21474282, compound → HCID 21474392, compound

HRID 2294260Notes

Reaction equation

HRID 2294260 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([OH:27])[C:9]1[N:10]([CH2:24][CH2:25][OH:26])[CH:11]=[CH:12][C:13](=[O:23])[C:14]=1[O:15]CC1C=CC=CC=1>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([OH:27])[C:9]1[N:10]([CH2:24][CH2:25][OH:26])[CH:11]=[CH:12][C:13](=[O:23])[C:14]=1[OH:15]

Participants

3

Reactant 1

HCID 21474282HCID 21474282, compound

Product 1

HCID 21474392HCID 21474392, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrogenation of 1.5 g of 2-[(2-fluorophenyl)-hydroxy-methyl]-3-benzyloxy-1-(2-hydroxy-ethyl)-1H-pyridin-4-one analogously to Example 1and recrystallisation from ethanol yield 2-[(2-fluorophenyl)-hydroxy-methyl]-3-hydroxy-1-(2-hydroxy-ethyl)-1H-pyridin-4-one in the form of colourless crystals. M.p.: 177°-178° C.

Sources & evidence

ORD record
ord-5278d90ea98c40bdbc76c2a8d4f5c702
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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