Aluminium lithium hydride → HCID 21474721, compound

HRID 2294344Notes

Reaction equation

HRID 2294344 reaction equation
[CH3:1][N:2]([CH3:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[O:6][CH2:7][CH:8]([OH:13])[CH2:9][N:10]=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][N:2]([CH3:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[O:6][CH2:7][CH:8]([OH:13])[CH2:9][NH2:10]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21474773HCID 21474773, compound

Product 1

HCID 21474721HCID 21474721, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A procedure similar to that described in preparation 13 was repeated, except that 2.41 g of 3-(3-dimethylaminophenoxy)-2-hydroxypropylazide (prepared as described in Preparation 80), 0.76 g of lithium aluminum hydride and 50 ml of anhydrous tetrahydrofuran were used, to give 1.80 g of the title compound having an Rf value of 0.9 (on silica gel thin layer chromatography, using a 4:1 by volume mixture of ethyl acetate and ethanol as the developing solvent).

Workup

  1. customA procedure similar to that described in preparation 13

Sources & evidence

ORD record
ord-ae579d516d564ff0a79e83a30dabef24
Source dataset
uspto-grants-1997_11
Patent number
US05688823

Reaction notes

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