反应详情

A solution of furan (1 mmole) in 1 mL diethyl ether was treated with N,N,N′N′-tetramethylethylenediamine (TMEDA) (1 mmole) and nBuLi (1.1 mmole) at −78° C. for 0.5 h. The resulting solution was cannulated into a solution of diethyl chlorophosphate (1.33 mmole) in I mL of diethyl ether at −60° C. and the reaction mixture allowed to rise to rt and stirred for another 16 h. Extraction and distillation at 75° C./0.2 mm produced diethyl 2-furanphosphonate as a clear oil.

1. customto rise to rt
2. extractionExtraction and distillation at 75° C./0.2 mm