HRID2294368

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13831

Tributylphosphine

C12H27P

HCID73042

1,1′-(1,2-Diazenediyl)bis[1-(1-piperidinyl)methanone]

C12H20N4O2

结构：O=C1SC(Cc2ccc(O)cc2)C(=O)N1C(c1ccccc1)(c1ccccc1)c1ccccc1

HCID2818126

未命名化合物

HCID21474781

未命名化合物

PRODUCTS

生成物

结构：O=C1OC(COc2ccccc2)CN1CCCOc1ccc(CC2SC(=O)N(C(c3ccccc3)(c3ccccc3)c3ccccc3)C2=O)cc1

HCID21474751

未命名化合物

收率 55.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

A procedure similar to that described in Preparation 6 was repeated, except that 1.29 g of tributylphosphine, 30 ml of anhydrous benzene, 2.98 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 1.61 g of azodicarbonyldipiperidine and 1.33 g of 3-(5-phenoxymethyl-2-oxooxazolidin-3-yl)propanol (prepared as described in Preparation 114) were used, to give 2.04 g of the title compound, melting at 70° C. to 73° C.

WORKUP

后处理

customA procedure similar to that described in Preparation 6

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-08ab48cad0e54045b13a26165a2f091d
来源数据集: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05688823
来源说明: uspto-grants-1997_11

反应 SMILES

C(P(CCCC)CCCC)CCC.[OH:14][C:15]1[CH:47]=[CH:46][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[N:22]([C:26]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]2=[O:45])=[CH:17][CH:16]=1.N(C(N1CCCCC1)=O)=NC(N1CCCCC1)=O.[O:66]([CH2:73][CH:74]1[O:78][C:77](=[O:79])[N:76]([CH2:80][CH2:81][CH2:82]O)[CH2:75]1)[C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1>C1C=CC=CC=1>[O:66]([CH2:73][CH:74]1[O:78][C:77](=[O:79])[N:76]([CH2:80][CH2:81][CH2:82][O:14][C:15]2[CH:16]=[CH:17][C:18]([CH2:19][CH:20]3[S:24][C:23](=[O:25])[N:22]([C:26]([C:39]4[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=4)([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[C:21]3=[O:45])=[CH:46][CH:47]=2)[CH2:75]1)[C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1