反应详情

Sodium hydroxide (1 mL, 2N) was added to a solution of 2-(3-chloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid methyl ester (122 mg, 0.43 mmol) in THF (4 mL) and methanol (1 mL). The mixture was stirred for 4 hours then evaporated to dryness. Ethyl acetate was added and removed in vacuo three times to afford crude 2-(3-chloro-phenyl)-imidazo[1,2-a]pyridine-7-carboxylic acid sodium salt (quantitative yield) which was used without further purification. m/z (M+H)=273.1.

1. customthen evaporated to dryness
2. additionEthyl acetate was added
3. customremoved in vacuo three times