Trimethyl phosphite → 1-[1-(3,3-Dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-2-methylprop-1-en-1-yl dimethyl phosphate

HRID 229456Notes

Reaction equation

Br[C:2]([CH3:24])([CH3:23])[C:3]([C:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH3:15])=[CH:11][CH:12]=2)[N:7]([CH2:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[N:6]=1)=[O:4].[P:25]([O:30]C)([O:28][CH3:29])[O:26][CH3:27]>>[P:25]([O:28][CH3:29])([O:26][CH3:27])([O:4][C:3]([C:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH3:15])=[CH:11][CH:12]=2)[N:7]([CH2:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[N:6]=1)=[C:2]([CH3:24])[CH3:23])=[O:30]

Participants

Reactant 2

HCID 8472Trimethyl phosphite

HCID 68852612HCID 68852612, compound

Product 1

HCID 115319381-[1-(3,3-Dimethyl-2-oxobutyl)-6-methoxy-1H-indazol-3-yl]-2-methylprop-1-en-1-yl dimethyl phosphate

Procedure

Reaction of 1-[3-(2-bromo-2-methylpropanoyl)-6-methoxy-1H-indazol-1-yl]-3,3-dimethylbutan-2-one from the above with trimethyl phosphite using the procedure as described in Method I Step B above provided the title compound identical to the one obtained with Method I.

Sources & evidence

ORD record: ord-462df64910ad4115a41668825ddb4083
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07563816B2

Reaction notes

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