Prop-2-en-1-yl 4-aminobenzoate → Allyl 4-(alpha-fluoro-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetamido)benzoate

HRID 2294568Notes

Reaction equation

HRID 2294568 reaction equation
[F:1][CH:2]([C:6]1[CH:15]=[CH:14][C:13]2[C:12]([CH3:17])([CH3:16])[CH2:11][CH2:10][C:9]([CH3:19])([CH3:18])[C:8]=2[CH:7]=1)[C:3](O)=[O:4].[NH2:20][C:21]1[CH:32]=[CH:31][C:24]([C:25]([O:27][CH2:28][CH:29]=[CH2:30])=[O:26])=[CH:23][CH:22]=1>>[F:1][CH:2]([C:6]1[CH:15]=[CH:14][C:13]2[C:12]([CH3:17])([CH3:16])[CH2:11][CH2:10][C:9]([CH3:19])([CH3:18])[C:8]=2[CH:7]=1)[C:3]([NH:20][C:21]1[CH:22]=[CH:23][C:24]([C:25]([O:27][CH2:28][CH:29]=[CH2:30])=[O:26])=[CH:31][CH:32]=1)=[O:4]

Participants

3

Reactant 2

HCID 13075143Prop-2-en-1-yl 4-aminobenzoateHCID 21474586alpha-Fluoro-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid

Product 1

HCID 53834800Allyl 4-(alpha-fluoro-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetamido)benzoate

Procedure

In a manner similar to Example 4(c), by reaction of 1.35 g (5.1 mmol) of α-fluoro-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid with 920 mg (5.1 mmol) of allyl 4-aminobenzoate, 1.7 g (81%) of ester are obtained in the form of an oil.

Workup

  1. customare obtained in the form of an oil

Sources & evidence

ORD record
ord-6876a97bed634594890e6c9eb6dd666c
Source dataset
uspto-grants-1997_11
Patent number
US05688817

Reaction notes

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