Water → 3-(1-Adamantyl)-4-methoxyaniline

HRID 2294570Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294570
[C:1]12([C:11]3[CH:12]=[C:13]([CH:21]=[CH:22][C:23]=3[O:24][CH3:25])[NH:14]C(=O)C(F)(F)F)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.O.[OH-].[K+]>CO>[C:1]12([C:11]3[CH:12]=[C:13]([CH:21]=[CH:22][C:23]=3[O:24][CH3:25])[NH2:14])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH2:8]1)[CH2:10]2

Komponenten

5

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 190682803-(1-adamantyl)4-methoxy-N-(trifluoroacetyl)aniline

Produkt 1

HCID 80271163-(1-Adamantyl)-4-methoxyaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

11.03 g (31.2 mmol) of 3-(1-adamantyl)4-methoxy-N-(trifluoroacetyl)aniline dissolved in 40 ml of methanol and 160 ml of water are treated with 7.12 g (51.5 mmol) of potassium hydroxide. The reaction medium is heated to 50° C. for 20 hours and then 80° C. for 18 hours. After evaporation to dryness, the residue is taken up with ethyl ether, the insoluble matter is filtered off and the filtrate is dried over magnesium sulphate and evaporated. The solid is washed in hexane to yield, after drying, 7.44 g (93%) of 3-(1-adamantyl)-4-methoxyaniline, melting point 140°-141° C.

Aufarbeitung

  1. customAfter evaporation to dryness
  2. filtrationthe insoluble matter is filtered off
  3. dry with materialthe filtrate is dried over magnesium sulphate
  4. customevaporated
  5. washThe solid is washed in hexane
  6. customto yield
  7. customafter drying

Quellen und Nachweise

ORD-Eintrag
ord-c3bcb8b2ce1a4c8a8201322045d73206
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688817

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