Isopropyl iodide → HCID 21474510, compound

HRID 2294586Notes

Reaction equation

HRID 2294586 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:18]=[CH:19][C:20]=1[OH:21])[C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].I[CH:29]([CH3:31])[CH3:30]>C(C(C)=O)C>[C:1]([C:5]1[CH:6]=[C:7]([CH:18]=[CH:19][C:20]=1[O:21][CH:29]([CH3:31])[CH3:30])[C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 21474535HCID 21474535, compound

Product 1

HCID 21474510HCID 21474510, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

5.7 g (0.02 mol) of benzyl 3-tert-butyl-4-hydroxybenzoate, 7 g (0.05 mol) of finely ground potassium carbonate, 4 ml (0.04 mol) of 2-iodopropane and 100 ml of methyl ethyl ketone are introduced under nitrogen into a three-necked flask. The mixture is heated to reflux for 24 h, the inorganic matter is filtered off and the filtrate is evaporated. The residue is taken up with ethyl ether and water and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 24 h
  3. filtrationthe inorganic matter is filtered off
  4. customthe filtrate is evaporated
  5. customthe organic phase is separated after settling
  6. dry with materialdried over magnesium sulphate
  7. customevaporated

Sources & evidence

ORD record
ord-fbfe486d07a84a838ab5c938d20c2295
Source dataset
uspto-grants-1997_11
Patent number
US05688817

Reaction notes

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