HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3,3-dimethylpentan-2-one → Cyclopentylidene[1-(3,3-dimethyl-2-oxopentyl)-6-methoxy-1H-indazol-3-yl]methyl dimethyl phosphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3,3-dimethylpentan-2-one | HCID 12822307 | — |
| Reactant | Cyclopentylidene(6-methoxy-1H-indazol-3-yl)methyl dimethyl phosphate | HCID 68850940 | — |
| Product | Cyclopentylidene[1-(3,3-dimethyl-2-oxopentyl)-6-methoxy-1H-indazol-3-yl]methyl dimethyl phosphate | HCID 68852053 | — |
Reaction Steps
The title compound was prepared from cyclopentylidene(6-methoxy-1H-indazol-3-yl)methyl dimethyl phosphate from Step B Example 6 and 1-Bromo-3,3-dimethylpentan-2-one from Step A Example 4 using the procedure described in Method I Step C of Example 1 followed by RP-HPLC purification using 35˜100% MeCN gradient without TFA. It was obtained as a colorless solid after lyophilization. LC-MS: 3.70 min. (m/Z=339.2, 465.2, 487.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563816B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-9b0ff9388c334eb3a19b5626fa04a8f0 |
| Source note | uspto-grants-2009_07 |