HCID 15126588, compound → HCID 86751657, compound

HRID 2294726Notes

Reaction equation

HRID 2294726 reaction equation
C(S(C[C@@H](CC1C=CC=CC=1)C(N[C@H:13]([C:32]([OH:34])=O)[CH2:14][C:15]1[N:19]=[CH:18][N:17]([C:20]2[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][C:21]=2[N+:29]([O-:31])=[O:30])[CH:16]=1)=O)(=O)=O)(C)(C)C.[NH2:42][C@@H:43]([CH2:51][CH:52]1[CH2:57][CH2:56][CH2:55][CH2:54][CH2:53]1)[C@@H:44]([OH:50])[C:45]([CH:47]1[CH2:49][CH2:48]1)=[O:46]>>[CH:52]1([CH2:51][C@H:43]([NH:42][C:32](=[O:34])[CH2:13][CH2:14][C:15]2[N:19]=[CH:18][N:17]([C:20]3[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][C:21]=3[N+:29]([O-:31])=[O:30])[CH:16]=2)[C@@H:44]([OH:50])[C:45]([CH:47]2[CH2:48][CH2:49]2)=[O:46])[CH2:53][CH2:54][CH2:55][CH2:56][CH2:57]1

Participants

3

Reactant 2

HCID 15126588HCID 15126588, compoundHCID 67723857HCID 67723857, compound

Product 1

HCID 86751657HCID 86751657, compound

Procedure

In an analogous manner to that described in Example 23, by condensing N-[(S)-α-[(tert-butylsulphonyl)methyl]hydrocinnamoyl]-1-(2,4-dinitrophenyl)-L-histidine and (2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-2-hydroxy-1-butanone there is obtained (S)-α-[(S)-α-(tert-butylsulphonyl)methyl]hydrocinnamamido]-N-[(1S,2R)-1-(cyclohexylmethyl)-3-cyclopropyl-2-hydroxy-3-oxopropyl]-1-(2,4-dinitrophenyl)imidazole-4-propionamide as a yellow solid, MS: 795 (M+H)+.

Sources & evidence

ORD record
ord-d5fcb237246f4c16bbc8c1a660fa9a13
Source dataset
uspto-grants-1997_11
Patent number
US05688946

Reaction notes

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