Cyclohexanol → Cyclohexyl 5-amino-4-oxopentanoate--hydrogen chloride (1/1)

HRID 229474Notes

Reaction equation

HRID 229474 reaction equation
[CH:1]1([OH:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15].S(Cl)([Cl:20])=O>>[ClH:20].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14]([O:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:15]

Participants

4

Reactant 3

HCID 7966CyclohexanolHCID 24386Thionyl ChlorideHCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 22253131Cyclohexyl 5-amino-4-oxopentanoate--hydrogen chloride (1/1)

Procedure

From cyclohexanol (6.0 ml) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol) at 80° C. Thionyl chloride was added at room temperature. The reaction was complete after 3 h. The yield was 1.48 g (99%).

Workup

  1. customat 80° C

Sources & evidence

ORD record
ord-3b16eaa2e69f4a5cab47b1ead0702698
Source dataset
uspto-grants-2009_07
Patent number
US07563819B1

Reaction notes

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