HCID 21471076, compound → HCID 21471077, compound

HRID 2294771Notes

Reaction equation

HRID 2294771 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([NH:7][C:8]([C:13]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=1)([CH3:12])[C:9]([OH:11])=[O:10])=O>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[O:10][C:9](=[O:11])[C:8]([CH3:12])([C:13]3[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=3)[N:7]=2)[CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 1

HCID 21471076HCID 21471076, compound

Product 1

HCID 21471077HCID 21471077, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

3.17 g (0.01M) of 2-(m-chlorobenzamido)-2-(p-tolyl)propionic acid was dissolved in 30 ml of acetic anhydride and the resulting solution was heated for 1 hr with reflux. The reaction solution was cooled and distilled out acetic anhydride in vacuo. The residue was subjected to chromatography, to give 2.4 g of the object compound, pure oily compound: 80 % Yield.

Workup

  1. temperaturethe resulting solution was heated for 1 hr
  2. temperaturewith reflux
  3. temperatureThe reaction solution was cooled
  4. distillationdistilled out acetic anhydride in vacuo

Sources & evidence

ORD record
ord-6ff59dc55bd74773b4f6ccb561f82c7f
Source dataset
uspto-grants-1997_11
Patent number
US05691278

Reaction notes

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