3-(Trifluoromethyl)phenol → HCID 21471071, compound

Participants

Reaction Steps

Sodium hydride (0.31 g (ca. 60% in mineral oil), 0.0035×2.2 mol) was suspended in 20 ml of N-methyl-2-pyrrolidinone, then meta-trifluoromethyl phenol (1.24 g, 0.0035×2.2 mol) was added thereto, and the resultant solution was heated to about 60° C. and stirred for several minutes. After allowed to cool to room temperature, to the reaction solution was added 4-cyano-2,6-dichloropyridine (0.60 g, 0.0035 mol), and then the mixture was allowed to react for 1 hour at about 90° C.

Provenance & Evidence