3-(Trifluoromethyl)phenol → HCID 21471071, compound

HRID 2294777Notes

Reaction equation

HRID 2294777 reaction equation
[H-].[Na+].[F:3][C:4]([F:13])([F:12])[C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1.[C:14]([C:16]1[CH:21]=[C:20](Cl)[N:19]=[C:18](Cl)[CH:17]=1)#[N:15]>CN1CCCC1=O>[C:14]([C:16]1[CH:21]=[C:20]([O:11][C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([C:4]([F:12])([F:13])[F:3])[CH:6]=2)[N:19]=[C:18]([O:11][C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([C:4]([F:3])([F:12])[F:13])[CH:6]=2)[CH:17]=1)#[N:15]

Participants

5

Reactant 3

HCID 73763-(Trifluoromethyl)phenolHCID 24758Sodium hydrideHCID 7359062,6-Dichloroisonicotinonitrile

Product 1

HCID 21471071HCID 21471071, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Sodium hydride (0.31 g (ca. 60% in mineral oil), 0.0035×2.2 mol) was suspended in 20 ml of N-methyl-2-pyrrolidinone, then meta-trifluoromethyl phenol (1.24 g, 0.0035×2.2 mol) was added thereto, and the resultant solution was heated to about 60° C. and stirred for several minutes. After allowed to cool to room temperature, to the reaction solution was added 4-cyano-2,6-dichloropyridine (0.60 g, 0.0035 mol), and then the mixture was allowed to react for 1 hour at about 90° C.

Workup

  1. customto react for 1 hour at about 90° C.

Sources & evidence

ORD record
ord-2a89d0a74f454b3d831f63f031a73475
Source dataset
uspto-grants-1997_11
Patent number
US05691277

Reaction notes

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