Chloromethyl pivalate → HCID 10383563, compound

HRID 2294780Notes

Reaction equation

HRID 2294780 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]([CH2:7][O:8][C:9]2[C:10]3[N:14]=[CH:13][NH:12][C:11]=3[N:15]=[C:16]([NH2:18])[N:17]=2)=[CH:5][CH:6]=1.[O-]CC.[Na+].[C:23]([O:29][CH2:30]Cl)(=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25]>C(O)C>[NH2:18][C:16]1[N:15]=[C:11]2[C:10]([N:14]=[CH:13][N:12]2[CH2:30][O:29][C:23](=[O:28])[C:24]([CH3:27])([CH3:26])[CH3:25])=[C:9]([O:8][CH2:7][C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=2)[N:17]=1

Participants

5

Reactant 3

HCID 87885Chloromethyl pivalateHCID 2723922Sodium ethoxideHCID 178508945HCID 178508945, compound

Product 1

HCID 10383563HCID 10383563, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 0.24 g (1 mmol) of O6 -benzylguanine under argon was added 1 mL of a 1M solution of sodium ethoxide in ethanol. The homogeneous solution was stirred for 10 minutes. The ethanol was then removed under vacuum. The remaining solid was dissolved in 2 mL of dry DMF. Chloromethyl pivalate (0.145 ml, 1 mmol) was added dropwise to the stirred solution. The mixture was allowed to react for 30 minutes at room temperature. The DMF was removed under vacuum. The residue was triturated with a small volume of 10% ethanol in CHCl3 and the soluble material was loaded on a 2.5×17 cm silica gel column (Davisil grade 633, 200-425 mesh, 60 Å). The product was eluted with 10% ethanol in CHCl3. Yield, 257 mg (72%); mp 161°-162° C.; 1H NMR δ1.09 (s, 9 H, (CH3)3), 5.48 (s, 2 H, CH2N<), 5.96 (s, 2 H, BzlCH2), 6.64 (s, 2 H, NH2), 7.34 (cm, 1 H, p-ArH), 7.39 (cm, 2 H, 2 m-ArH), 7.50 (cm, 2 H, 2 o-ArH), 7.92 (s, 1 H, 8-H); 13C NMR δ26.51 ((CH3)3), 38.20 (C(CH3)3), 65.13 (CH2N), 66.94 (BzlCH2), 113.11 (C-5), 128.05 (p-Ar), 128.38 (2 m-Ar), 128.47 (2 o-Ar), 136.50 (ipso-Ar), 139.96 (C-8), 154.30 (C-4), 160.11 (C-2), 160.18 (C-6), 176.96 (CO2); MS (EI) Calcd. m/z for C18H21N5O3 : 355.1644. Found: 355.1660 (5 ppm error). Anal. Calcd. for C18H21N5O3 : C, 60.83; H, 5.96; N, 19.71. Found: C, 61.11; H, 6.07; N, 19.64.

Workup

  1. customThe ethanol was then removed under vacuum
  2. dissolutionThe remaining solid was dissolved in 2 mL of dry DMF
  3. customto react for 30 minutes at room temperature
  4. customThe DMF was removed under vacuum
  5. customThe residue was triturated with a small volume of 10% ethanol in CHCl3
  6. washThe product was eluted with 10% ethanol in CHCl3
  7. customYield

Sources & evidence

ORD record
ord-7be3744cd4504dc79d192e9185dcb6b8
Source dataset
uspto-grants-1997_11
Patent number
US05691307

Reaction notes

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