Allyl iodide → HCID 54537716, compound

HRID 2294785Notes

Reaction equation

[CH2:1](I)[CH:2]=[CH2:3].[NH2:5][C:6]1[N:10]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([C:18]([F:21])([F:20])[F:19])=[CH:13][C:12]=2[Br:22])[N:9]=[C:8]([C:23](=[S:25])[NH2:24])[C:7]=1[S:26]([CH3:28])=[O:27]>>[CH2:1]([S:25][C:23]([C:8]1[C:7]([S:26]([CH3:28])=[O:27])=[C:6]([NH2:5])[N:10]([C:11]2[C:16]([Cl:17])=[CH:15][C:14]([C:18]([F:21])([F:20])[F:19])=[CH:13][C:12]=2[Br:22])[N:9]=1)=[NH:24])[CH:2]=[CH2:3]

Participants

Reactant 2

HCID 11166Allyl iodide

HCID 10298328HCID 10298328, compound

Product 1

HCID 54537716HCID 54537716, compound

Procedure

In a manner similar to that described in EXAMPLE 2, allyl iodide was reacted with 5-amino-1-[2-bromo-6-chloro-4-(trifluoromethyl)phenyl]-4-methylsulfinyl-1H-pyrazole-3-carbothioamide (Compound 6, prepared as described in applicants' concurrently filed, copending application referenced in EXAMPLE 2 above) to give 5-amino-1-[2-bromo-6-chloro-4-(trifluoromethyl)phenyl]-4-methylsulfinyl-1H-pyrazole-3-carboximidothioic acid 2-propenyl ester having a melting point of about 91° C. This compound is referred to hereinafter as Compound 3.

Workup

customprepared

Sources & evidence

ORD record: ord-d61ed1e52c31427d85b0e84d6a906287
Source dataset: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05691333

Reaction notes

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