4-Chlorobenzenesulfonyl isocyanate → HCID 10811871, compound

HRID 2294794Notes

Reaction equation

HRID 2294794 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22])=[CH:17][CH:16]=1>C1C=CC=CC=1>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([S:21]([NH:24][C:25]([N:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[O:26])(=[O:22])=[O:23])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 1385874-Chlorobenzenesulfonyl isocyanateHCID 11298576Glycine, N-(4-chlorophenyl)-, methyl ester

Product 1

HCID 10811871HCID 10811871, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Three grams (15 mmol) of methyl 4-chlorophenylaminoacetate were dissolved in 40 ml of benzene, and 2.2 ml (15 mmol) of 4-chlorobenzenesulfonyl isocyanate were added to the resultant solution, followed by stirring for 1 hour. Crystals formed were collected by filtration to obtain N-(4-chlorobenzenesulfonyl)-N'-(4-chlorophenyl)-N'-methoxycarbonylmethylurea (6.1 g) as white crystals.

Workup

  1. customCrystals formed
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-7d9b3ce45bba4a698289daa6aee57ff6
Source dataset
uspto-grants-1997_11
Patent number
US05691335

Reaction notes

Loading…