HCID 10551549, compound → HCID 10572734, compound

HRID 2294804Notes

Reaction equation

HRID 2294804 reaction equation
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][C:17](=[O:19])[N:16]([S:20]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)(=[O:22])=[O:21])[C:15]2=[O:30])=[CH:10][CH:9]=1)=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:6]([C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:18][C:17](=[O:19])[N:16]([S:20]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)(=[O:21])=[O:22])[C:15]2=[O:30])=[CH:12][CH:13]=1)([OH:7])=[O:5]

Participants

3

Reactant 1

HCID 10551549HCID 10551549, compound

Product 1

HCID 10572734HCID 10572734, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In 1.5 ml of trifluoroacetic acid (TFA), were dissolved 120 mg (0.27 mmol) of 1-(4-t-butoxycarbonylphenyl)-3-(4-chlorobenzenesulfonyl)-imidazolidin-2,4-dione obtained in Example 53. The resultant solution was stirred at room temperature for 10 minutes. The liquid reaction mixture was concentrated under reduced pressure and added with diethyl ether. Crystals deposited were collected by filtration to obtain 90 mg (yield: 85.2%) of the title compound.

Workup

  1. customThe liquid reaction mixture
  2. concentrationwas concentrated under reduced pressure
  3. additionadded with diethyl ether
  4. filtrationCrystals deposited were collected by filtration

Sources & evidence

ORD record
ord-65edb96b20314554af865e6990be3288
Source dataset
uspto-grants-1997_11
Patent number
US05691335

Reaction notes

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