1-Benzylpiperazine → 1-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine

HRID 2294877Notes

Reaction equation

HRID 2294877 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]([C:10]([OH:12])=O)[CH2:7][C:6]=2[CH:13]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]([C:10]([N:24]3[CH2:25][CH2:26][N:21]([CH2:14][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:22][CH2:23]3)=[O:12])[CH2:7][C:6]=2[CH:13]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 131024035-Fluoro-2,3-dihydro-1-benzofuran-2-carboxylic acid

Product 1

HCID 214722611-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine

Procedure

0.03 mol of 1-[(5-fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine (resulting from the condensation of 5-fluoro-2,3-dihydrobenzofuran-2-carboxylic acid with N-benzylpiperazine) is dissolved in 150 ml of anhydrous tetrahydrofuran (T.H.F.). Two times 0.03 mol of lithium aluminum hydride are added in the form of pellets. The mixture is stirred at room temperature. The title compound is obtained.

Sources & evidence

ORD record
ord-1154c08401d94ffdb6bd97a2d2570282
Source dataset
uspto-grants-1997_11
Patent number
US05691340

Reaction notes

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